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TOPAMAX® (topiramate) is an antiepileptic drug proven to reduce the frequency of seizures, particularly among patients who are not controlled by other antiepileptic drugs (AEDs). TOPAMAX is indicated as adjunctive therapy for adults and pediatric patients ages 2-16 years with partial onset seizures or primary generalized tonic-clonic seizures and in patients 2 years of age and older with seizures associated with Lennox-Gastaut Syndrome.
Topamax medication has been studied in more than one million epilepsy patients worldwide.
Although the exact mechanism of action is unknown, Topimax Topiramate appears to work in three ways to help balance electrical activity in the brain to reduce the frequency of seizures. Specifically, TOPAMAX enhances a chemical substance that inhibits electrical activity in the brain, while blocking other substances that increase activity.
Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures, or electrical disturbances in the brain that can alter a patient's consciousness, movement or behaviors. Seizures are characterized as either partial or generalized, depending on where they originate in the brain.
TOPAMAX was discovered and developed by the R.W. Johnson Pharmaceutical Research Institute and is marketed in the United States by Ortho-McNeil Pharmaceutical. Both companies are located in Raritan, NJ.
In the pediatric trial, the most common side effects associated with TOPAMAX as add-on therapy included excessive drowsiness, loss of appetite, fatigue, nervousness, difficulty with concentration/attention, weight decrease, aggressive reaction and difficulty with memory. The safety and effectiveness in patients younger than two have not been established.
In adults, the most common side effects were somnolence, dizziness, coordination problems, speech disorders, psychomotor slowing, abnormal vision, difficulty with memory, sensory distortion and double vision.
